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Deoxyhypusine synthase : ウィキペディア英語版 | Deoxyhypusine synthase
Deoxyhypusine synthase (, ''spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)'') is an enzyme with system name ''(eIF5A-precursor)-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming)''. This enzyme catalyses the following chemical reaction : ()-lysine + spermidine ()-deoxyhypusine + propane-1,3-diamine (overall reaction) : (1a) spermidine + NAD+ dehydrospermidine + NADH : (1b) dehydrospermidine + ()-lysine N-(4-aminobutylidene)-()-lysine + propane-1,3-diamine : (1c) N-(4-aminobutylidene)-()-lysine + ()-lysine N-(4-aminobutylidene)-()-lysine + ()-lysine : (1d) N-(4-aminobutylidene)-()-lysine + NADH + H+ ()-deoxyhypusine + NAD+ The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. == References ==
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